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KMID : 0371420231050030133
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Annals of Surgical Treatment and Research
2023 Volume.105 No. 3 p.133 ~ p.140
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Donor sex and donor-recipient sex disparity do not affect hepatocellular carcinoma recurrence after living donor liver transplantation
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Oh Rak-Kyun
Hwang Shin
Song Gi-Won
Ahn Chul-Soo
Moon Deok-Bog
Han Sang-Ah
Jung Dong-Hwan
Park Gil-Chun
Yoon Young-In
Kang Woo-Hyoung
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Abstract
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Purpose : Studies have yielded contradictory results on whether donor sex and donor-recipient sex disparity affect hepatocellular carcinoma (HCC) recurrence after living donor liver transplantation (LDLT). The present study assessed whether donor sex or donor-recipient sex disparity affects HCC recurrence after LDLT at a high-volume center.
Methods : This study included 772 HCC patients who underwent LDLT between January 2006 and December 2015 at Asan Medical Center. Patients were divided into 4 groups based on the sex of the donor and recipient: male-to-male (n = 490, 63.5%), male-to-female (n = 75, 9.7%), female-to-male (n = 170, 22.0%), and female-to-female (n = 37, 4.8%).
Results : Disease-free survival (DFS; P = 0.372) and overall survival (OS; P = 0.591) did not differ significantly among the 4 groups. DFS also did not differ significantly between LDLT recipients with male and female donors (P = 0.792) or between male and female recipients (P = 0.084). After patient matching with an α-FP/des-γ-carboxy prothrombin/tumor volume score cutoff of 5logs, donor-recipient sex disparity did not significantly affect DFS (P = 0.598) or OS (P = 0.777). There were also no differences in DFS in matched LDLT recipients with male and female donors (P = 0.312) or between male and female recipients (P = 0.374).
Conclusion : Neither donor sex nor donor-recipient sex disparity significantly affected posttransplant HCC recurrence.
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KEYWORD
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Androgens, Donor selection, Donor sex, Hepatocellular carcinoma, Sex disparity
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